What Is Rejuran? Variants, How It Works, and Aftercare

Rejuran is a polynucleotide (PN/PDRN) skinbooster derived from salmon DNA, injected into the skin to help support its repair processes and resilience. It comes in several variants your doctor can choose based on your goals, is done as a course of several sessions, and produces results that appear gradually and vary by individual.

What Is Rejuran (PN/PDRN)?

Rejuran is an injectable product in the “skinbooster” category whose main ingredient is polynucleotide (PN), a long-chain fragment of genetic material (DNA) that has been extracted and purified from salmon DNA. It is made by Pharma Research (PharmaResearch) of South Korea.

PN belongs to the same family as PDRN (polydeoxyribonucleotide), a shorter DNA fragment. Both have a long history of research support in dermatology and wound healing. One studied mechanism is that PDRN acts like an agonist of the adenosine A2A receptor, which is associated with stimulating tissue repair, forming new blood vessels, and reducing inflammation in models of slow-healing wounds (PubMed, 2021).

Put simply, when Rejuran is injected into the dermis, PN gradually works at the cellular level, helping to “signal” the skin to carry out its repair and conditioning processes. This makes it different from fillers, which focus on “adding volume,” because Rejuran emphasizes skin quality, such as smoothness, elasticity, and hydration, more than reshaping the face. That said, results vary by individual.

A point many people wonder about is whether “salmon DNA” is safe for human skin. The scientific explanation is that the structure of genetic material across living organisms is fundamentally similar, so DNA extracted from salmon is biocompatible with human skin to a degree, and before use it goes through a purification process to reduce proteins that could trigger allergies. Even so, injecting any substance into the skin always carries the possibility of side effects, so it should be done with an experienced doctor at a properly accredited facility, using products with a clear source.

If you want to understand the bigger picture of how skinboosters and mesotherapy differ, read more on the skinbooster / mesotherapy service page.

How Many Variants Are There, and How Do They Differ (e.g., Healer, HB, Eye, S)?

Rejuran comes in several variants on the market, with the main differences being PN concentration, the viscosity of the product, and added ingredients, which makes each variant suited to different areas and goals. Your doctor assesses and selects the variant that suits each person’s skin. The commonly seen variants are as follows.

The property details of each variant are based on the manufacturer and several dermatology clinics (PharmaResearch). Variant names and details may differ by country and product batch, and the choice of which variant to use should always be made under the judgment of an experienced doctor.

For first-timers, many people start with the Healer or HB variant because these address overall skin conditioning and hydration, while the Eye and S variants are often used for more specific goals. In actual treatment, a doctor may consider using more than one variant together in each round, or adjust the variant based on how the skin responds each time. So no single variant suits everyone, and assessing your skin condition before starting is a step that should not be skipped.

What Skin Concerns Can It Help With?

Based on the mechanism of polynucleotides and PDRN, which have research support for tissue repair, Rejuran may help care for skin in the following areas (results vary by individual).

• May help improve overall skin quality so it looks smoother and more elastic
• May help add hydration and care for skin that looks dry or dull, especially the HA-blended variant
• May help care for shallow fine lines and delicate areas such as around the eyes (Eye variant)
• May help condition acne scars and deep grooves (S variant)
• May help support the strength of the skin barrier by stimulating repair processes

There is a literature review noting that PDRN gives positive effects in terms of healing time and skin regeneration in the context of wound healing (PubMed Systematic Review, 2020). However, its use in aesthetics is individual-specific, and you should assess it with a doctor to set appropriate expectations. Note that Rejuran is not intended to directly treat pigmentation concerns.

How Many Sessions, and When Do Results Show?

Doctors generally plan a course of about 3 to 4 sessions spaced roughly 2 to 4 weeks apart, so the skin gradually responds to cumulative stimulation. After that, repeat sessions may follow for ongoing care as advised by the doctor. The appropriate frequency and number of sessions depend on your skin condition, goals, and the variant chosen, so a doctor should assess this on an individual basis.

In terms of how long results take, information from clinics and most medical sources indicates that improvements in skin quality tend to be gradual and cumulative, with changes possibly becoming noticeable from around 4 to 6 weeks onward and often becoming clearer after completing the course. Results and timing vary by individual and cannot be stated with certainty as being the same for everyone.

The key point is that Rejuran emphasizes “conditioning and repair” more than immediately visible change, so it suits those who want long-term skin care and understand that results appear gradually.

In some cases a doctor may recommend doing Rejuran alongside other procedures, such as laser or other types of skinboosters, for holistic skin care, spacing and sequencing them appropriately to reduce cumulative irritation. This kind of planning requires individual assessment by a doctor; you should not perform multiple procedures on your own without consultation, as this may increase the risk to your skin.

How Many Days Do Bumps Last, and How to Care for Skin?

After a Rejuran injection, many people may see tiny raised bumps (micro-papules), redness, or mild swelling at the injection site, which is a response that can occur. Clinical sources indicate that these bumps usually subside within about 24 to 48 hours, and the surface of the skin typically settles within about 3 to 4 days, while mild localized inflammation may last around 2 to 5 days depending on the depth and area treated (Cosmetic Connection). This timing varies by individual.

Basic aftercare guidance that is commonly recommended:

• Cleanse the skin gently and avoid scrubbing or massaging the injection site for the first 24 hours
• Apply sunscreen and avoid intense sun exposure in the early period
• Pause potent skincare (such as exfoliating acids and retinoids) for about the first 24 to 48 hours
• Avoid heat, saunas, vigorous exercise, and alcohol for the first 1 to 2 days
• You can generally wear makeup after about 24 to 48 hours, if your doctor permits

If you have unusually severe redness or swelling, increasing pain, or signs of infection, contact the clinic or your doctor immediately. Following your doctor’s aftercare instructions is an important part of helping your skin recover appropriately.

Who Is It Suitable For?

Rejuran may be an option worth considering for people with the following characteristics, though you should always assess with a doctor first.

• Those who want to care for overall skin quality, dull skin, or skin lacking smoothness or elasticity
• Those who want to emphasize skin hydration (the HA-blended variant suits this)
• Those concerned about thin skin in the eye area
• Those who have acne scars or deep grooves and want to condition their skin
• Those who understand that results appear gradually and require a course of sessions

That said, those who are pregnant or breastfeeding, those with a history of allergy to the product’s ingredients, those with an infection or inflamed rash at the treatment area, or those with certain underlying conditions may not be suitable or may need additional individual assessment. So you should give your doctor a complete health history before deciding.

Approximate Price

The price of Rejuran depends on several factors, including the variant chosen (such as Healer, HB, Eye, S), the number of sessions in the course, the area, and the number of vials used, so it can only be given as a broad range and may differ across clinics and time periods. An accurate price estimate should be made after the doctor examines your skin and plans a treatment that suits you.

To get price information that truly matches your needs and skin condition, we recommend asking via LINE for initial guidance and to book an assessment with a doctor.

Summary

Rejuran is a polynucleotide skinbooster derived from salmon DNA that emphasizes skin quality by stimulating the skin’s natural repair processes. It comes in several variants your doctor can choose based on your goals, including Healer, HB, Eye, and S. Results appear gradually and vary by individual. If you are interested, consult an experienced doctor to plan what suits your skin.

If you would like initial guidance or an assessment of which variant suits your skin, the Onnyx Clinic medical team is glad to advise. Ask questions and book an appointment via LINE @onnyxclinic.

References

• Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing — PubMed (2021)
• The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a systematic review — PubMed (2020)
• Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives — PMC
• PharmaResearch (manufacturer of Rejuran) — official website
• Rejuran Downtime & Recovery Timeline — Cosmetic Connection